Descriptif

Description and pedagogical objectives

Mastering/modulating the properties of (bio)materials with molecular functionalization is a challenging task to improve their performance and/or endow them with new chemical/biological functions enabling detection of biomarkers or analytes. The goal of this course is to address the main strategies to modify the surface of the main families of (bio)materials with (bio)molecules and the main schemes for biodetection.

The course is divided into three blocks:   

• the description of the main families of (bio)materials and nanomaterials including their synthesis and their characteristics in terms of physical, mechanical and chemical properties.
• the preparation and activation procedures of the materials together with their chemical functionalization using plasma polymerization, physical deposit or (electro)chemical grafting. Strategies to design antimicrobial coatings will be also discussed.
• the biodetection of analytes including O₂, signaling molecules, metabolites, biomarkers, and pathogens using optical (fluorescence, surface plasmon resonance, surface-enhanced Raman scattering), magnetic, piezoelectric or electrochemistry approaches.

In parallel, several lab sessions will be dedicated to the syntheses and characterization of noble metal particles for the optical detection of analytes.

Prequesite

Basic knowledge in chemistry of materials

Evaluation

Students are evaluated on the basis of a written exam (2/3) and a final oral presentation (1/3)